Single-cell RNA sequencing (scRNA-seq) has confirmed that MM exhibits high intra-tumor heterogeneity, comprising a mixture of ...

CAR-T cell therapy is a breakthrough in cancer immunotherapy. The treatment is available in India at a fraction of the cost abroad. Among the many emerging treatments for cancer, there's one called ...

a biotechnology company developing engineered immunoglobulin A (IgA) antibodies, to create the world’s leading pan-isotype cancer antibody company. As a result of the combination of these two ...

Purpose: To identify the specific intratumoral and microenvironmental heterogeneity of acral (AM ... while AM was enriched with PI16⁺ cancer-associated fibroblasts (CAFs) promoting tumor proliferation ...

This heterogeneity complicates the consistent delivery of therapeutic agents ... CAR-T cell therapy involves modifying a patient’s T cells to express chimeric antigen receptors that recognize specific ...

1Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee. Search for other works by this author on: 2Department of Computational Biology, St. Jude Children’s Research ...

Chimeric antigen receptor (CAR ... These barriers include an immunosuppressive tumor microenvironment, tumor heterogeneity, lack of specific targets, and deregulated immune control mechanisms.

HealthDay News — Black and American Indian patients are less likely to have elevated cancer antigen (CA)-125 levels at ovarian cancer diagnosis, according to a study published in JAMA Network Open.

including non-small cell lung cancer and head and neck cancer. It utilizes mRNA encoding multiple TAAs encapsulated in a lipid nanoparticle (LNP) delivery system. Following intramuscular injection, ...

EVM14 received U.S. FDA clearance for its IND application, becoming Everest's first internally discovered program, and the first mRNA therapeutic cancer vaccine to be cleared for global clinical ...