Signaling pathways downstream of TLRs are tightly regulated for preventing collateral damage and loss of tolerance toward commensals. To trigger effective intracellular signaling, these receptors ...

Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety ...

After decades of hype and setbacks, scientists have made impressive progress into tricking stem cells into repairing organs. Stem cells (like the ones above, growing in petri dishes) are able to ...

In the heart, several AKAPs play a critical role in modulating multiple signaling pathways at the basis of cardiac physiopathology (Table). 20 This review will especially focus on the importance of ...

Nearly 30 years ago, Australia's first genetically modified field crop was planted: Bt cotton. CSIRO scientists helped develop this insect-resistant cotton variety, using a gene derived from a ...

Bt cotton works by producing a protein that kills the cotton bollworm—one of the crop's major pests—when it feeds on its leaves. It's used by cotton growers in Australia and around the world ...

We aim to quantitatively evaluate the processes of merging similar or functionally-related signaling pathways together by linking them with protein-protein interaction (PPI) data. We presented a ...

EV functional impact was assessed with endothelial angiogenesis assays. Carotid plaques contained more EVs than adjacent marginal zones, with differential enrichment for EV-microRNAs and EV-proteins ...

The receptor for IL-33, ST2, is present in multiple isoforms, including a membrane-bound form (ST2L), which together with the interleukin-1 (IL-1) receptor accessory protein forms the ...

Notably, this increase was unaffected by blocking the conventional ER-to-Golgi trafficking protein pathway and the exosomal release pathway, thus confirming that PARK7 was released via an ...

Turbulent blood flow can activate many signaling pathways, such as increased inflammatory cytokine expression and reactive ... In some experiments, the cells were preincubated with YAP-TAZ inhibitor ...