Nature Reviews Genetics - Telomeres have long been implicated in processes of cellular ageing. ... A schematic drawing that illustrates the typical range of telomere lengths by age in, ...

Cells with a single short telomere and lacking telomerase mount a damage response consisting of recruitment of DNA damage checkpoint proteins, Cdc13, RPA and Rad52, many generations before ...

Telomere crisis, which occurs during tumorigenesis when short telomeres become dysfunctional, is hypothesized to be a major source of the instability observed in cancer genomes (Figure 1). Telomere ...

Telomeres are important to human health because dysregulation of either telomere protection or telomerase activity causes many human diseases. Notably, over 90% of human cancers activate telomerase ...

Healthful Living May Lengthen Telomeres And Lifespans : Shots - Health News As people age, caps called telomeres on the ends of their chromosomes shrink. The observation has led some scientists to ...

Telomere dysfunction and cancer. The G-richness and highly repetitive nature of telomeric DNA pose major challenges to the DNA replication machinery. In the lab, we recently highlighted a role for the ...

Telomere testing for consumers offers a poor measure of “biological age,” says Johns Hopkins oncologist Mary Armanios.

BEIJING -- Scientists have successfully completed the world's first telomere-to-telomere (T2T) genome assembly of hexaploid bread wheat, marking a major breakthrough in wheat genome research.

Telomeres are structures made of repetitive DNA and protein, safeguarding our genetic material during cell division. Over time, these caps shorten, eventually reaching a point where cells can no ...

Longer leukocyte telomeres are linked to a lower risk for stroke, dementia, and late-life depression (LLD), early research suggests. The findings also indicated that adopting a healthy lifestyle ...