早期，针对无法手术的高危晚期或复发性肺癌，化疗和放疗是主要的治疗手段，但患者的总生存期改善有限。后来，新辅助化疗开始被探索用于肺癌治疗，然而早期化疗药物存在毒性高、副作用严重、治疗效果不稳定以及术后死亡率高等问题，使得这一治疗方式的接受度不高。随着免疫疗法的兴起，新辅助免疫疗法为肺癌治疗带来了新的希望，众多临床试验纷纷展开，对这一治疗方式进行深入探究。

研究人员利用重建的东亚气候历史编码系列（REACHES）气候数据库和自行构建的中国古代疫情数据库，对公元 1784 - 1787 年中国古代的极端干旱事件进行了细致研究。他们深入分析了粮食价格、人口密度、社会经济状况等多种因素，试图探索极端干旱事件对疫情爆发的时空影响机制以及影响程度。

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