Transient receptor potential vanilloid 1 (TRPV1) affects mood and neuroplasticity in the brain, where its role is poorly understood. In the present study we investigated whether capsaicin (8 ...

A computational analysis of cryo-EM data defines the binding mode of capsaicin on TRPV1. A mutational analysis validates these findings, showing specific van der Waals and hydrogen-bonding ...

TRPV1最初是作为辣椒素（capsaicin）受体被发现的，因此也被称为辣椒素受体或香草素受体1，其发现者David Julius教授凭借在发现感知温度受体上的突出 ...

本研究针对白内障术后后囊膜混浊（PCO）这一常见并发症，探究了TRPV1通道通过钙蛋白酶（Calpain）-蛋白酪氨酸磷酸酶（PTP）通路抑制晶状体上皮细胞上皮-间质转化（EMT）的分子机制。研究人员通过体外和离体实验证实，TRPV1激动剂辣椒素（Capsaicin）通过激活Calpain和PTPN9介导的EGFR去磷酸化，显著抑制 ...

辣椒素-TRPV1相互作用机制。图片来源：Molecules [4] 最近，ACS Reactions小组做了一个勇敢的吃辣实验[5]，他们发现牛奶并不是最佳的解辣饮品，相比之下 ...

Thus, capsaicin-induced inward currents are composed of two components: TRPV1-mediated Na+ influx and anon efflux through anotamin 1 activated by Ca2+ ions entering cells through TRPV1.

Thus, capsaicin-induced inward currents are composed of two components: TRPV1-mediated Na+ influx and anon efflux through anotamin 1 activated by Ca2+ ions entering cells through TRPV1.

Spicy food may support a healthier microbiome, too. Though data are limited, “spicy foods appear to increase the microbiome’s ...

Drs. Takayama and Tominaga in National Institute for Physiological Sciences -- Okazaki Institute for Integrative Bioscience -- clarified that an interaction between capsaicin receptor TRPV1 and ...

Capsaicin is the main ingredient in ointments, lotions, and patches used for pain relief. It interacts with a nerve receptor called TRPV1, which is present in the brain, peripheral nerves, bladder ...