Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) receptors, which are ...

Figure 2.TRPV1 mutant F660S ablates proton activation but not capsaicin or heat activation. (A)An amino‐acid sequence alignment of part of the pore region, including the upper third of TMD6 of human ...

Results TRPV1 receptor occupancy derived from plasma levels and factoring a plasma/lung ratio of 1, was approximately 45% at 2hrs and 25% at 24hrs. This translated to a 4 fold shift in the capsaicin ...

Spicy food may support a healthier microbiome, too. Though data are limited, “spicy foods appear to increase the microbiome’s ...

本研究针对白内障术后后囊膜混浊（PCO）这一常见并发症，探究了TRPV1通道通过钙蛋白酶（Calpain）-蛋白酪氨酸磷酸酶（PTP）通路抑制晶状体上皮细胞上皮-间质转化（EMT）的分子机制。研究人员通过体外和离体实验证实，TRPV1激动剂辣椒素（Capsaicin）通过激活Calpain和PTPN9介导的EGFR去磷酸化，显著抑制 ...

But more research would be needed to confirm this interaction, says Jie Zheng of the University of California, Davis, who studies the capsaicin-TRPV1 system and was not involved in the recent paper.

The German pharma acquired rights to the TRPV1 agonist also known as MTX-071 last year ... Grünenthal already sells a topical capsaicin product called Qutenza for post-shingles nerve pain ...

Scientists have discovered a novel way to relieve pain by targeting TRPV1, a key ion channel involved in sensing heat and physical discomfort ...

Ohio State researchers discovered three natural compounds—capsianoside I, roseoside, and gingerglycolipid A—that reduce the perceived spiciness of chili peppers without altering their capsaicin levels ...

The compounds may work by interfering with TRPV1 receptors, ... Each sample contained the same amount of capsaicin and dihydrocapsaicin, roughly equivalent to 800 Scoville units, ...

Dietary capsaicin further reduced the increased αENaC activity in WT mice attributed to the HS diet. In contrast, this capsaicin effect was absent in TRPV1 –/– mice. Immunoprecipitation study ...

They act on TRPV1 receptors, the same pain sensors that register spicy heat in your mouth. These receptors are also found throughout the body and are targets for pain relief therapies. Capsaicin ...