Investigating TLR4 expression in benign and malignant ovarian tumors in situ and its signaling in human OvCa cell lines, we show that TLR4 has a significant function in growth of ovarian tumor ...

Cell Signaling, Beverly, MA, USA). Two-hybrid screening was done as described with a mixed human fetal brain and spleen cDNA library. 28 A portion of human TLR4 spanning the sequence encoding the ...

Further analysis identified a molecular signaling pathway underlying the inhibitory effects of TLR4 triggering on CD4+ T cell inflammatory function, providing insight into the regulation of CD4+ T ...

Gum disease caused by the bacteria Porphyromonas gingivalis is linked to worse multiple sclerosis (MS) in a mouse model of ...

Specifically, these mice have low levels of free iron in immune cells known as macrophages and this impairs signaling along a ... an inflammatory response (the TLR4/TRAM/TRIF pathway).