Gum disease caused by the bacteria Porphyromonas gingivalis is linked to worse multiple sclerosis (MS) in a mouse model of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Toll-like receptor 4 (TLR4) signaling at the ...

BOSTON--(BUSINESS WIRE)--#AntibodyDiscovery--Leveragen Inc., a Boston-based biotechnology company specializing in next-generation genetic models for antibody discovery, today announced a comprehensive ...

为探究成年心脏成纤维细胞中细胞自主免疫信号如何调控纤维化，来自印度 Amrita Vishwa Vidyapeetham 的研究人员开展了关于 TLR4 信号在心脏成纤维细胞中作用的研究。结果表明，抑制 TLR4 信号可调节体外纤维化变化。这为治疗心脏损伤后的纤维化提供了新方向。

Targeting the TLR4 signalling has recently been suggested as a promising approach for alleviating IRI by affecting inflammation, oxidative stress and programmed cell death (PCD). In this minireview, ...

Here, we identify disulfiram (DSF), an FDA-approved drug for alcoholism, as a specific inhibitor of TLR4-mediated inflammatory signaling. TLR4 cell surface expression, LPS sensing, dimerization and ...

2712), all from Cell Signaling Technologies (Danvers, MA). As a loading control, anti-GAPDH (1:2500, no. 9485; Abcam, Cambridge, MA) was used. Densitometry quantification of protein expression was ...

Introduction RP105 is a structural homolog of TLR4 and an important regulator of TLR4 signaling. RP105 enhances TLR4 signaling in B-cells while it dampens the TLR4 response on myeloid cells. B-cells ...

Infection and tissue damage induces assembly of supramolecular organizing centres (SMOCs)), such as the Toll-like receptor (TLR) MyDDosome, to co-ordinate inflammatory signaling. SMOC assembly is ...