在探索腭裂发病机制的道路上，科学家们遇到了重重困难。一方面，遗传因素复杂多样，众多基因相互交织，难以理清头绪；另一方面，环境因素也错综复杂，各种因素之间的相互作用更是让研究难度加大。然而，这些困难并没有阻挡科学家们前进的脚步，他们坚持不懈地寻找着突破点。

Genetic testing of the 10 LDS-associated genes in the two probands showed that c.605C>T (JX001-II1) and c.679G>A (JX002-II1) variants were both positioned in exon 1 of TGFBR1 and it results in the ...

Although the relationship between cervical carotid tortuosity and cardiovascular risk in patients with Loeys-Dietz syndrome has been studied, it is unclear whether cervical carotid tortuosity ...

The authors bioinformatically analyze previous scRNA-seq datasets of the developing mouse soft palate to identify differential signaling pathway activities in the heterogeneous palatal mesenchyme.