研究团队首次发现，黑色素瘤细胞中一个名为琥珀酰辅酶A（Succinyl-CoA）的代谢分子，竟是操控免疫检查点PD-L1的"隐形操盘手"。 为何某些癌症患者对 ...

生物活性：Succinyl phosphonate trisodium salt 是一种 α-酮戊二酸脱氢酶 (KGDHC) 抑制剂，有效抑制 (KGDHC) 在肌肉、细菌、脑和培养的人成纤维细胞中[1 ][4]。 Succinyl phosphonate trisodium salt 是一种 2-oxoglutarate dehydrogenase (OGDH) ...

Succinylation is a post-translational modification that attaches a succinyl group to lysine residues, significantly altering the protein’s mass, charge, and conformation, affecting protein function ...

This mechanism is relevant for mutant FLT3-driven leukemogenesis. SUCLG1 reduces succinyl-CoA levels to restrict POLRMT succinylation. K622 succinylation suppresses POLRMT activity. FLT3 mutations ...

All animal procedures were conducted in accordance with the regulations of the Canadian Council on Animal Care and approved by the University of Alberta Health Sciences Animal Welfare Committee. The ...

琥珀酰DSPE-PEG是一种功能化的聚乙二醇（PEG）脂质偶联物。已用于构建脂质单层，用于合成包被姜黄素的纳米颗粒。 (DSPE)共轭聚乙二醇是磷脂和聚乙二醇结合具有亲水性和疏水性。聚乙二醇磷脂脂质体形成优质材料,可用于药物输送、基因转染和疫苗传递。聚乙二 ...

One such recently described gene is succinyl-CoA ligase, defects of which have been associated with mtDNA depletion in muscle. The patient was born by cesarean section at 36-wk gestation with ...

The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and have diverse roles in the ...

Here we show that for heterotrophic growth on acetate D. acetivorans uses a modified oxidative TCA cycle that was first discovered in acetate-oxidizing sulfate reducers in which a succinyl-CoA:acetate ...