RECENT clinical studies have demonstrated that osmotic diuresis, with or without urinary alkalinization, will accelerate the renal excretion of drug in patients with barbiturate intoxication. 1 ...

Barbiturates are a type of drug that slows down brain activity. Barbiturates have been used for several conditions, including ...

Barbiturates are illegal without a prescription and, in fact, are a controlled substance like narcotics. They can be highly addictive, and withdrawal may produce severe symptoms, including death.

Barbiturates were first developed in 1864 and became a popular sleeping pill. Between the 1920s and the mid-1950s, barbiturates were practically the only drugs used as sedatives and hypnotics.

Benzodiazepines, barbiturates and anaesthetics such as propofol act via specific adhesion sites on receptors that lie at contact points of nerve cells (synapses) in the brain and increase the ...

These drawbacks to self-destruction, as ticked off by Dorothy Parker, do not apply to an overdose of sleeping pills. In recent years the barbiturates have enjoyed alarming popularity as a painless ...

Valium and other modern tranquilizers largely replaced barbiturate drugs 30 years ago. However, barbiturates are still detectable among the pharmaceutical and personal care products that wind up ...

Objectives: To evaluate high-dose barbiturates as a second-tier therapy for pediatric refractory intracranial hypertension complicating severe traumatic brain injury. Design: This is a ...