To investigate the potential conformational change induced by c-di-GMP binding, we have determined the structure of ligand-free STING CTD at 1.9-Å resolution. Superposition of the ligand-free ...

Two studies reveal the first full-length structure of the elusive STING protein attached to different molecules in the pathway. STING is a key member of an important pathway in innate immunity ...

That side-by-side structure is the same as one reported in a recent preprint from Lingyin Li’s group at Stanford University that proposes mechanisms for STING activation, inhibition, and ...

Researchers have unlocked the structure of a key protein that, when sensing certain viruses and bacteria, triggers the body's immediate immune response. Researchers at Weill Cornell Medical ...

Efficient and site-specific genome engineering can be achieved based on programmable nucleic acid cleavage using CRISPR-Cas surveillance complexes. Structure-function studies on single component Cas ...

Hao Wu, professor of Biochemistry at Weill Cornell Medical College. "The STING structure provides a remarkable example of the pathogen-host interactions in which a unique microbial molecule ...