Protein concentration was determined using the BCA protein concentration determination kit. Western blot was used to detect apoptosis and protein expression of JAK2/STAT3 signaling pathway, as ...

School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China ...

The suppressor of cytokine signaling-3 (SOCS3) is an inducible negative regulator of the JAK/STAT pathway, implicated in various inflammatory diseases. In this study, we investigated the role of SOCS3 ...

这项研究发现指出了提高癌症疗法效果的新途径，提升了CAR-T细胞疗法治疗血液癌症（如淋巴瘤和白血病）的可能性。改进后的CAR-T细胞不仅能更好地抵御肿瘤，还能在体内保持长期活性，从而降低癌症复发的风险。目前，研究人员正在探索是否可以用相同的基因修饰方法来治疗其他类型的癌症，特别是实体瘤，尽管用当前的方法治疗这些肿瘤仍面临挑战。

and Jak/Stat3 (pStat3) signaling in MG. Further, inhibition of S1P synthesis decreased ATF3, mTor (pS6) and pSmad1/5/9 levels in activated MG in damaged retinas. By contrast, inhibition of NFκB ...

ORLANDO -- More than 40% of patients with longstanding prurigo nodularis (PN) had significant improvement within 3 months of ...

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The Trump administration has started quietly re-hiring some of the FDA employees that it fired last week in a process that insiders called abrupt and haphazard, STAT’s Lizzy Lawrence reports. The ...

Understanding these pathways could lead to the development of therapeutic agents to combat hypertension. "In the amygdala, the gene Stat3 is involved ... Potential role of signal transducer ...