Figure 4: DSBs accumulate predominantly in the late S/G 2 phase of the cell cycle. Transgenic mice were created by injection of the MT construct into C57BL/6 oocytes. Four founder lines were ...

The findings suggest that somatic growth deceleration primarily results not from an increase in cell-cycle time but from a decrease in growth fraction (fraction of cells that continue to proliferate).

and found that somatic cells have almost no activation of telomerase during three phase of cell cycle. The level of TERT mRNA and active telomerase in most phases of cell cycle (G0/G1, G1/S ...

Cell cycle speed is key to making aging cells young again Date: January 30, 2014 Source: Yale University Summary: Researchers identified a major obstacle to converting cells back to their youthful ...

We can now say that regulated activation of telomerase at a critical point in a cell’s life cycle serves an important ... In normal somatic body cells telomeres shorten at each cell division ...

The cell cycle relies on ubiquitin and the SCF complex plays an integral role in the regulation of this process. Ubiquitin ligase also regulates ubiquitinylation by stimulating the degradation of ...

Company to showcase preclinical studies of ARV-393, an investigational oral PROTAC BCL6 degrader, as a single agent in models ...