Vascular SMC differentiation in embryonic development is recognized by the appearance of cytoskeletal and contractile protein isoforms, including SMα-actin (Acta2), SM-calponin (Cnn1), and SM-myosin ...

B, RNase protection assay showing MEF2C expression in RASMCs. Total RNA (25 μg) was hybridized, digested, and electrophoresed as described in “Materials and Methods.” Smooth muscle myosin heavy chain ...

Dysfunction of smooth muscle can lead to a range of challenging diseases, including hypertension, asthma, irritable bowel syndrome, overactive bladder, and leiomyoma, among others. Despite extensive ...

Myosin II molecules assemble and form filaments through their C-terminal rod region, and the dynamic filament assembly−disassembly process of nonmuscle myosin II molecules is important for cellular ...

MT-125 is a selective inhibitor of non-muscle myosin II (NMII), a molecular motor protein that drives tumor proliferation and invasion, resistance to therapy and oxidative stress, and immune evasion.

Muscle is a soft tissue composed of elongated cells (muscle fibres) that produce force and motion through contraction. Involuntary cardiac and smooth muscles are responsible for contraction of the ...

Enlargement, Reduction, and Even Reversal of Relative Migration Speeds of Endothelial and Smooth Muscle Cells on Biomaterials Simply by Adjusting RGD Nanospacing. Junhao He. Junhao He. State Key ...

Interestingly, MmMYL3 is not the first myosin protein to be identified as a viral receptor. Previous studies have shown that non-muscle myosin IIA acts as a receptor for herpes simplex virus (Arii et ...

Smooth muscles take longer to contract than skeletal muscles do, but they can stay contracted for a long time because they don't tire easily. Cardiac muscle is found in the heart. The walls of the ...

Recent studies underscore their significance in various viral infections. For instance, myosin heavy chain 9 has been identified as a crucial factor for various virus infection (Li et al., 2018).