From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...

KRAS mutations drive approximately 25% of human cancers, with KRAS G12D being the most prevalent and challenging to target. Recent advances have led to developing small molecule inhibitors that ...

"This is a breakthrough as for the first time we can demonstrate that a small molecule can help improve the function of defective DNA polymerase. Our results pave the way for a completely new ...

Janus kinase (JAK) inhibitors were associated with more infections ... and shorter follow-up periods for newer treatments. Small sample sizes limited dose-dependent risk analysis, and vaccination ...

GLP-1 RAs and SGLT2 inhibitors significantly reduce cardiovascular events and heart failure risk in older adults with type 2 diabetes compared to DPP-4 inhibitors. The study utilized health ...

US biotech start-up RayThera has secured $110 million in series A financing to fund the early clinical development of its small molecule drug candidates in immunology. The round was led by healthcare ...

Here we report the cryo-EM structure of ligand-free, G protein-free C3aR, providing insights into its inactive conformation. In addition, we determine the structures of C3aR in complex with the ...

“Natural products are an important source of small-molecule probes in chemical biology. They are also crucial tools for exploring life phenomena, regulating biological functions, and studying ...

In a 2019 study in mice, Choi and Huh showed that in some cases of infection, IL-17 is released and suppresses a small region of ... reduced sociability. "This molecule became a link that connects ...

As 2025 unfolds, the entrepreneurial landscape is ripe with opportunities for aspiring small business owners. Technological advancements, evolving consumer preferences, and emerging market trends have ...

(Photo by Alex Wong/Getty Images) When President Donald Trump announced a new round of tariffs on April 2nd, small business owners were quick to start doing the math. It didn’t take much figuring.

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, China; Department of Molecular, Cellular, ...