Widespread neuronal mitochondrial complex I (CI) deficiency was recently reported to be a characteristic in a subgroup of individuals with idiopathic Parkinson's disease (PD). Here, we sought to ...

AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) peptide has garnered attention for its intriguing biological properties ...

Nowadays, the prevalence of sedentary lifestyles and high-caloric diets leads to an imbalance between energy intake and ...

A new drug may one day help fight obesity and related diseases by mimicking the benefits of aerobic exercise—without the need ...

Background Muscle wasting and weakness (sarcopenia) are commonly associated with COPD causing frailty and reduced quality of ...

In skeletal muscles, mitochondrial dysfunction- the cell's powerhouse- and decreased glucose use efficiency all contribute to metabolic diseases. According to the authors, the study's findings ...

This study demonstrates the effectiveness of in vivo mitochondrial gene therapy using a novel mtZFN architecture on skeletal muscle using adeno-associated viral (AAV) platforms in a murine model ...

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) significantly impacts patient quality of life and prognosis. Skeletal muscle mass loss, a systemic manifestation of ...