Brain cells receive sensory inputs from the outside world and send signals throughout the body telling organs and muscles ...

A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation. They are particularly deleterious as the DNA ends can ...

The following is a summary of “Faulty Gap Filling in Nucleotide Excision Repair Leads to Double-Strand Break Formation in ...

Could viral infections play a role in Huntington's disease? Research suggests Apolipoprotein B mRNA editing catalytic ...

Key TakeawaysBerkeley Lab researchers and their Harvard collaborators examined cell type and brain region specific features ...

APOBEC enzymes, which normally help fight viral infections by mutating viral DNA, cause repeat expansions and are unusually ...

Researchers at Tufts University revealed a possible molecular mechanism explaining how the DNA repeats are broken and then expanded in the Huntington’s disease gene, pointing to a component of the ...

Efficient DNA repair mechanisms have evolved to ensure ... polymerase η; SSB, single-strand break; TCR, transcription-coupled repair. Abbreviations: BER, base excision repair; DSB, double-stand ...

People genetically susceptible to Huntington's disease often see their movement, mood, and cognition decline slowly over time.

Simulation of DNA damage using improved DBSCAN ... clustering -gui 7 - OUTPUT The output results containing for each event: - the yield of single strand break - the yield of complex single strand ...

When cells attempt to fix the breaks, repeat expansions occur ... from cytosine nucleotides in single stranded virus DNA, mutating the genetic code and ultimately rendering viral genes useless.