(A single colony arises from one cell going ... Singh, R. K. & Krishna, M. DNA strand breaks signal the induction of DNA double-strand break repair in Saccharomyces cerevisiae.

They can also be produced when DNA replication forks encounter DNA single-strand breaks or other types of lesion. They can occur at the termini of chromosomes due to defective metabolism of ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Scientists have provided the most detailed account yet of the earliest stages of DNA replication, an essential process for ...

This new research illustrates how small breaks in one strand of DNA can expand into a large single-stranded DNA gap that kills drug-resistant breast BRCA mutant cancer cells. The novel ...

These mechanisms can detect and correct different types of DNA damage, such as base mismatches, single-strand breaks, and double-strand breaks. DNA repair is essential for preventing the accumulation ...

New precision genome editing technologies are transforming the therapeutic landscape for patients with certain cancers and ...

For DNA to replicate, the helix must first unwind and break the DNA from a double strand into two single strands. Upon binding, helicases melt the DNA, breaking the chemicals bonds holding the ...

DNA ligases IIIa (922 amino acids) and IIIb (862 amino acids) are the products of a single gene; they differ in amino acid sequence only at their ... DNA ligase IV is a 911-amino acid polypeptide that ...

illustrates how a small DNA nick—a break in one strand of the DNA—can expand into a large single-stranded DNA gap, killing ...

RecA is a bacterial protein that is crucial for repairing double-stranded breaks in DNA via the process of homologous recombination. RecA binds to single-stranded DNA, searches along a separate piece ...