Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells.

The promise of genome editing to help understand human diseases and create new therapies is vast, but technological ...

Single-Stranded DNA The molecule of the hereditary material deoxyribonucleic acid (DNA) normally consists of two interwoven strands. The discovery of a form with only one strand promises to ...

First, they fabricated a universal single-strand DNA, as well as library of hundreds of short, single DNA strands called bricks. Each brick is composed of 24 nucleotides, including cytosine sites ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such ...

Recently, Professor Frédéric Veyrier at the Institut national de la recherche scientifique (INRS) and his team developed a new genetic tool based on a family of specific enzymes called Ssn that allows ...

A new family of enzymes enables precise cuts in single-stranded DNA, offering powerful new tools for genetic engineering and expanding possibilities in biotechnology. (Nanowerk News) A few years ago, ...

Single-stranded DNA is less common than double-stranded DNA. It is often found in some viruses and plays a key role in certain biological processes, such as cell replication or repair. Single ...

Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other genetic diseases. Almost all of these mosaic mutations begin as nucleotide mismatches or damage ...

The team initially set out to study another replication machinery protein, single-stranded DNA-binding protein, and its interaction with DNA polymerase. However, they first needed to establish how the ...

More information: Haichao Zhao et al, Distinct regulation of ATM signaling by DNA single-strand breaks and APE1, Nature Communications (2024). DOI: 10.1038/s41467-024-50836-6 Journal information ...