or PFC make local synapses within VTA. This work challenges the presumption of GABA interneurons in VTA by providing direct evidence for an alternative model by which GABA projection neurons can ...

health.sa.gov.au Background To address the growing burden of disease and long waiting lists for sleep services, a simplified two-stage model was developed and validated for identifying obstructive ...

We evaluated antinociceptive efficacy of the potent GABA-AT inhibitor OV329 in rodent models of neuropathic and inflammatory pain and assessed possible side effects (i.e., reward and motor impairment) ...

Our study provides significant insights into the role of transsynaptic nanoalignment in modulating synaptic strength, particularly in inhibitory synapses. Through modeling and superresolution imaging, ...

While the understanding of GABA's action at the synapse between pre- and post-synaptic neurons has been established, its effects outside the synapse have remained a mystery. Since 2010 ...

Chemical synapses are characterized by presynaptic vesicle cycling, neurotransmitter diffusion, and postsynaptic receptor activation, which eventually lead to postsynaptic currents and subsequent ...

20 input changes are required besides the actual structure changes in the simulation model. Simplified simulation model. Critical sections of the LNG terminal simulation model are discussed here to ...

The harm that measurements derived from over-simplified models can cause to the health of complex self-adaptive social systems has become evident with the recent imbroglio of the World Bank’s ...

The resulting efflux of GABA from the astrocyte to the synaptic space reflects an important astrocytic mechanism for modulation of hyperexcitability. Key results also illustrate an astrocytic-mediated ...