Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3. Molecular Psychiatry, 2022; DOI: 10.1038/s41380-021-01390-w; ...

Image of a cortical neuron (white) expressing serotonin 2A (5-HT2A) receptors (multicolor). New work shows that engaging 5-HT2A receptors inside cells, but not on the cell surface, encourages cell ...

The serotonin 2A (5-HT 2A) receptor is widely distributed in the brain and plays a critical role in perception, cognition and psychosis. It is also responsible for the psychedelic effects of drugs ...

The serotonin 2a receptor consistently emerged as the most important predictor of how DMT affected brain control energy. This reinforces the idea that DMT’s effects are specifically tied to its ...

Drug receptors are usually thought of as being on the cell membrane, facing out. But the researchers found that in nerve cells, serotonin 2A receptors were concentrated inside cells, mostly around ...

Classic psychedelics such as psilocybin and LSD bind to the 5-hydroxytryptamine 2A (5-HT 2A) receptor, an important G-protein-coupled receptor (GPCR) that’s involved in cellular signaling. But ...

A new paper has turned science’s understanding of how psychedelics affect the brain upside down by solving a longstanding molecular mystery in the field. Psychedelics are thought to produce their ...

The receptor, called serotonin 2A/C, is believed to play a key role in helping a sleeping infant wake up and gasp for air in response to oxygen deprivation. Related.

Prior research suggests that psychedelics' beneficial effects may stem from their ability to activate serotonin 2A receptors, which, in turn, encourages brain cells to forge new connections with ...

Drug receptors are usually thought of as being on the cell membrane, facing out. But the researchers found that in nerve cells, serotonin 2A receptors were concentrated inside cells, mostly around a ...