Serine hydrolases are one of the largest and most diverse classes of enzymes found in eukaryotes and prokaryotes, including ∼240 members in humans. Several clinically approved drugs target ...

Figure 1: ABHD6 hydrolyzes 2-AG in BV-2 cells and controls the efficacy of 2-AG at CB 2 receptors. Figure 3: Effect of WWL70 and JZL184 on [3 H]–2-AG hydrolysis and 2-AG accumulation in intact ...

Previously discovered serine hydrolase-blocking compounds have been turned into drugs to treat obesity, diabetes, and Alzheimer's disease, and are currently in testing as treatments for pain ...

Team hopes easily modified compounds will provide new insights into function of serine hydrolase enzymes. Scientists have developed a class of compounds they claim can be easily modified to ...

A new method that successfully designs serine hydrolase enzymes capable of catalyzing ester hydrolysis with high efficiency, demonstrates a computational approach for creating de novo enzymes that ...

successfully designed functional serine hydrolase enzymes capable of efficiently catalyzing ester hydrolysis from minimal active site specification. Moreover, they used their approach to uncover ...

Abide has pioneered innovative technologies to selectively target serine hydrolases, one of the largest enzyme families involved in regulating human physiology. Under the terms of the agreement ...

To test their cutting-edge approach, the UW researchers focused on a well-studied enzyme called a serine hydrolase. The ...

Crafting enzymes is more difficult than designing other proteins because it requires not just predicting the structure of a single protein conformation, but of changes in conformations as enzymes ...

Thermo Fisher Scientific, has announced the introduction of novel reagents for the study of active serine hydrolases. The Thermo Scientific ActivX Serine Hydrolase Probes contain a fluorphosphonate ...

Previously discovered serine hydrolase-blocking compounds have been turned into drugs to treat obesity, diabetes, and Alzheimer's disease, and are currently in testing as treatments for pain ...

Digital image of an AI-generated serine hydrolase enzyme created by UW researchers in David Baker’s lab. (UW Institute for Protein Design Image) Pellock compared the old approach to enzyme ...