"Using MrVI, we were able to understand which gene deletions changed the functions of the macrophages in a way that made them fight the tumor," says Sheban. One gene, called Zeb2, stood out on the ...

In Panel A, a patient flow diagram shows DNA sequencing and single ... population frequency, CADD score, known gene function, or available animal models. Details are provided in Table S8 in ...

Methods: Utilizing training and testing data, we evaluated multi-gene panels derived from commonly upregulated genes in publicly available AA patient datasets. The functions of these genes in ...

Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China ...

A schematic diagram of the molecular structure of Kv4.3. A Kv4.3 subunit containing six transmembrane ... 1130 C>T (p.T377M) mutation of the KCND3 gene was reported in the Chinese mainland family for ...

Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, providing their role in MYC activity is understood. Here we ...

Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA. Amanda was an associate editor at The Scientist, where she oversaw ...