The sarcomere is subdivided in several regions, called zones and bands, in which these filaments are arranged in different ways. The thin filament consists of F-actin, troponin, tropomyosin, and ...

Scientists have produced the first high-resolution 3D image of the sarcomere, the basic contractile unit of skeletal and heart muscle cells, by using electron cryo-tomography (cryo-ET).

Proteins of the FATZ family display intrinsic disorder. (A) Schematics of the striated muscle sarcomere and close-up view of F-actin/α-actinin/FATZ interactions in Z-disk.

To fully understand how the sarcomere functions and how it is regulated, we want to analyze it in different states e. g. during contraction“, says Raunser. Comparison with samples from patients with ...

Several disease genes encode components of the Z-disk (e.g., Cypher/ZASP), 49 the structure at the boundary of each sarcomere, or the costamere (e.g., δ-sarcoglycan), the structural complex that ...