Abstract: Recent advances in digital imaging have fuelled interest in using multiplex immunofluorescence (mIF) images to study multiple biomarkers ... highlighting the need for effective stain ...

为解决肺腺癌放疗耐药问题，研究人员探究 STAT1 对其细胞碳离子辐射敏感性影响，发现 STAT1-HO 1 轴可作放疗增敏靶点。 放疗是肺腺癌（LUAD）患者重要的治疗手段，然而放疗抵抗仍是治疗失败的主要因素。研究旨在阐明信号转导及转录激活因子 1（STAT1）如何在 ...

Hematoxylin-eosin staining and lung injury score were employed to evaluate pathological changes in mouse lungs. Total cell count in BALF was determined using a cell counter. Furthermore, western blot ...

Mechanistically, disruption of EGFR signaling generated a cell-intrinsic hypersensitivity within the JAK-STAT1 pathway, which, synergistically with interferon gamma expressing CD8 T-cell and ...

Functional role of MTX on osteoclastogenesis was assessed by trap staining and micro-computer tomography ... and signal transducer and activator of transcription 1 (STAT1), leading to the suppression ...

Immunofluorescence staining enables the detection and localization of antigens in diverse types of tissues in various cell preparations. AMSBIO has now launched CellO-IF, an immunofluorescence ...

In NRCMs expressing R120G, however, greater increases in p-STAT1 and STAT1 by interferon-γ were observed but segregated in the cytoplasmic protein aggregates rather than the nuclei, as unveiled by ...

aDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA bDepartment of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC, ...

Immunohistochemistry and immunofluorescence staining were performed as previously described [23 ... HK-2 cells seeded in 6-well plates were transfected with 20 nmol L −1 of STAT1 siRNA using ...

在本研究中，研究者利用遗传和生化分析，揭示了Thr748是STAT1中一个保守的干扰素非依赖性磷酸化开关，它限制干扰素信号转导，并在识别细菌衍生 ...