The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 (silent information regulator 2) regulates gene silencing in yeast and promotes lifespan extension during caloric restriction.

Targets of SIRT1 include transcriptional proteins that are important in energy metabolism, such as nuclear receptors, peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α), and ...

Several mechanisms may account for the effects of SirT1 on inflammation in vitro: SirT1 can induce transcriptional silencing by deacetylating histone 3 at lysine 9 (H3K9) and histone 4 at lysine ...

Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21. Gastroenterology , 2013; DOI: 10.1053/j.gastro.2013.10.059 Cite This Page : ...

Research investigates the effects of SIRT1 activation through resveratrol supplementation and energy restriction on vascular function in adults. The study reveals that both interventions increase ...

Researchers find changes to protein SirT1 Date: January 27, 2014 Source: Boston University Medical Center Summary: Studies have suggested that the protein SirT1 may be protective in metabolic ...

According to the researchers, a buckwheat-based diet helps to increase the level of SIRT1 protein that protects all the cells of the body and enhances longevity. In the same time, there is no need ...

SIRT1 has also been shown to interact with LXR to promote LXR activation. Additionally, previous literature has shown that starvation increases SIRT1 levels in mice. The purpose of this study was to ...

To test the impact of a SIRT1-activating drug in depressed mice, Prof. Lu and team knocked out the SIRT1 gene in male rodents and examined their reaction to a sweet drink that they would usually ...

Enter Sinclair et al and the latest Science article. The group found an SIRT1 mutant with complete immunity to activator molecules such as resveratrol and synthetic compounds from GSK/Sirtris.

HO-1 inhibits the activation of the TGF-ß/Smad3 pathway in NAFLD-related liver fibrosis through SIRT1. These findings provide insights into new therapeutic strategies for treating NAFLD ...