Pregabalin does not bind to plasma proteins. Pregabalin is eliminated primarily by renal excretion as an unchanged drug and has an elimination half-life of approximately 6 h. [14] For patients ...

Excretion of over 95% of ... pharmacodynamic properties of a parent drug and its active or inactive metabolites are greatly affected in patients with kidney disease and its resulting uremia.

Naringin and naringenin were mostly distributed in gastrointestinal tract, liver, kidney, lung, and trachea. Furthermore ... This study systemically investigated the pharmacokinetics, tissue ...

One of the pitfalls in caring for patients with heart failure is premature discontinuation of RAAS inhibitors when renal function declines during initiation or uptitration of the drugs. Worsening ...

Renal function, measured by creatinine clearance, phenolsulfonphthalein excretion and concentrating ability, continued to improve gradually. Asymptomatic hypertension and albuminuria were still ...

In the phase 3 ILLUMINATE-A trial reported in December, Alnylam’s drug met the primary objective of a significant reduction compared to placebo in urinary oxalate excretion over 24 hours ...

Buying Regulus ties neatly into Novartis' push into kidney disease therapies, with a portfolio that includes a trio of drugs to treat IgA nephropathy (IgAN) – two of which are already FDA ...

doctors.org.uk Objective 30 mm Hg drops in office systolic blood pressure are reported in trials of renal denervation, but ambulatory reductions are much smaller. This disparity is assumed to have a ...

Emergency drug treatments are outlined ... haemolytic uraemic syndrome (HUS). Renal function recovered completely after a period of haemodialysis and plasma exchange. Normal potassium homeostasis is ...

Hypophosphatemia associated with primary hyperparathyroidism is usually of moderate severity; increased urinary phosphate excretion is balanced by mobilization of phosphate from bone and enhanced ...