Role of RANKL in differentiation, fusion, activation and survival of osteoclasts. Osteoclast differentiation is a multistep process. Myeloid progenitor cells progressively differentiate into ...

The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...

Receptor activator of nuclear factor kappa B ligand (RANKL) stimulation induces the differentiation of macrophages into osteoclasts. Further, bone morphogenetic protein (BMP) and transforming ...

A new study in mice shows how the small GTPase Cdc42 influences bone modeling and remodeling—it modulates both the formation and function of osteoclasts, and is involved in the downstream ...

Furthermore, the anti-cANGPTL4 antibody was shown to mitigate RANKL-induced osteoclastogenesis ... thereby suppressing osteoclast activation. "Our work not only identifies a potential valuable ...