RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences ...

This process is known as RNA splicing and is tightly regulated to determine what protein isoforms are created from a pre-mRNA.Incorrect splicing of RNA can cause diseases such as β-thalessemia ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences ...

Dynamics are intrinsic to both RNA function and structure. Yet, the available means to precisely provide RNA-based processes with spatiotemporal resolution are scarce. Here, our work pioneers a ...

Background: Tumor heterogeneity and low mutational burden limits the availability of effective immunotherapy targets. Aberrant RNA-splicing (neojunctions) represents an underexplored yet promising ...

Ultimately, Stoke Therapeutics is that classic “intriguing biotech” --hurdling to one of those proverbial “moments of truth” ...

The new study, funded in part by the National Institutes of Health and published June 18 in Cell Chemical Biology, showed ...

A new documentary about Phil Sharp dives deeper into his story, from his roots growing up with dyslexia and in severe poverty ...

Circular RNAs (circRNAs) are stable, ring-shaped molecules that play crucial roles in brain development, cognition, and long-term cellular regulation.

癌症治疗领域迎来重磅发现！科学家们锁定了一种意想不到的"肿瘤身份证"——由RNA剪接错误（mis-splicing）产生的新抗原（neoantigen）。在剪接因子突变的髓系恶性肿瘤中，这些异常拼接的蛋白质片段就像癌细胞特有的"分子条形码"，为精准免疫治疗提供了理想靶点。

哈尔滨医科大学梁海海教授团队系统阐述了AS在肺癌、肺炎、哮喘、慢性阻塞性肺疾病、肺动脉高压和特发性肺纤维化等肺部疾病中的分子调控网络与临床价值。该综述深入探讨了AS事件作为复杂疾病治疗新靶点的重要意义，并全面解析了RNA剪接在肺部疾病中的前沿突破与诊 ...