Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences ...

Here, our work pioneers a reversible approach to regulate RNA splicing within primary patient-derived cells by synthetic photoswitches. Our small molecule enables conditional real-time control at mRNA ...

The new study, funded in part by the National Institutes of Health and published June 18 in Cell Chemical Biology, showed ...

癌症治疗领域迎来重磅发现！科学家们锁定了一种意想不到的"肿瘤身份证"——由RNA剪接错误（mis-splicing）产生的新抗原（neoantigen）。在剪接因子突变的髓系恶性肿瘤中，这些异常拼接的蛋白质片段就像癌细胞特有的"分子条形码"，为精准免疫治疗提供了理想靶点。

Skyhawk Therapeutics has dosed the first subject in the randomised Phase II/III FALCON-HD trial of the oral small-molecule ...

SKY-0515 is an oral small molecule designed to reduce the production of both huntingtin (HTT) and PMS1 proteins—two key drivers of HD pathology ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel ...

Methodological advances have enabled discoveries of RNA polymerase interactions with RNA processing machineries, such as the splicing and 3′-end cleavage machineries.

A team of Indian American scientists led by Pallavi Gopal are working to learn more about the dynamics of a protein to help ...

In the first half of 2025, researchers around the world have published a wave of peer-reviewed studies examining the effects ...