Read the paper: Tumour-wide RNA splicing aberrations generate actionable ... that arises from abnormal mRNA splicing. Splicing is a processing event in which non-coding segments called introns ...

Additionally, they note connections between TIGR-Tas systems and certain RNA-processing proteins in human cells. "I think there's more there to study in terms of what some of those relationships ...

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

Endogenous siRNAs exist and differ from miRNAs in that they are not derived from primary miRNA transcripts, and they do not undergo canonical miRNA processing. Rather, they can be derived from long ...

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In most eukaryotic cells, two types of spliceosome ... information—called introns—from the precursors of messenger RNA (pre-mRNA), the molecule responsible for transferring genetic information ...

G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA or RNA sequences. They play various regulatory roles in many biological ... with this activity predicted to ...

Automation and artificial intelligence (AI) will be key to a new effort to manufacture millions of RNA vaccines in Africa, according to Cairo, Egypt-headquartered drug firm Eva Pharma. Eva Pharma ...

STAR-RSEM pipeline based on: https://github.com/BD2KGenomics/toil-scripts/blob/releases/2.0.x/src/toil_scripts/rnaseq_cgl/README.md Annotations, Reference genome and ...

Many studies have used single-cell RNA sequencing (scRNA-seq) to infer gene regulatory networks (GRNs), which are crucial for understanding complex cellular regulation. However, the inherent noise and ...

UTRs contain crucial regulatory elements for RNA stability, translation and localization, so their integrity is indispensable for gene expression. Approximately 3.7% of genetic variants associated ...

Low-carbon future plans frequently overlook strategies to address corresponding supply shortfalls for two key refinery-sourced products critical to achieving a sustainable energy... TotalEnergies ...