RNA oligonucleotides capable of inducing controlled immunostimulation combined with specific oncogene silencing via an RNA interference (RNAi) mechanism provide synergistic inhibition of cancer cell ...

Argonaute (AGO) proteins bind to small RNAs to induce RNA interference (RNAi), a conserved gene regulatory mechanism in animal, plant, and fungal kingdoms. Small RNAs of the fungal plant pathogen ...

Key Takeaways. RNA interference (RNAi) offers a promising approach for AML patients with FLT3-ITD mutations, addressing challenges like drug resistance and high relapse rates.

Double-stranded RNA (dsRNA) can trigger the conserved mechanism of RNA interference (RNAi) to degrade mRNA of matching sequence (Fire et al., 1998), and thus silence gene expression, in many organisms ...

First-in-human Phase 1a/1b clinical trial will evaluate orally available, RGT-61159 designed to selectively target MYB RNA and inhibit oncogenic MYB protein production Preclinical data supporting the ...

ARO-APOC3, a hepatocyte-targeting RNA interference therapeutic, inhibits ApoC-III messenger ribonucleic acid expression, lowering triglyceride levels,” Daniel Gaudet, MD, PhD, professor of ...

RNA interference (RNAi) plays pleiotropic roles in animal cells, from the post-transcriptional control of gene expression via the production of micro-RNAs, to the inhibition of RNA virus infection. We ...

RNA interference (RNAi) is a key biological process that leads to the silencing of gene expression. RNAi can be initiated by a cell in response to pathogenic nucleic acids to bring about a ...

RNA interference (RNAi) is a widely applied method, offering a fast and easy system to study gene functions. In this talk, we will take a look at the technology of endoribonuclease-prepared siRNAs ...

A research team from the University of Cologne and collaborators has now shown that RNA interference, or RNAi for short, which is known to be a viral defense mechanism, also prevents the ...