During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

近日，东南大学智能材料研究院院长、首席科学家、化学化工学院李全团队在肿瘤光诊疗领域取得突破性进展，开发出一种新型基于近红外二区的J-聚集体纳米药物，为克服现有纳米药物在肿瘤治疗中的局限性提供了创新解决方案。相关成果以“In Situ ...

All of them partially reversed runaway cell death and inflammation following trauma, but the largest reversal involved blocking gasdermin D, a molecule that triggers pyroptosis cell death by opening ...

Active caspase 1 causes pyroptosis and is responsible for proteolytic maturation of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18. Pyroptosis is characterized by caspase 1 ...

Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and ...

1 Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China 2 Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing ...

Pyroptosis is a morphologically and mechanistically distinct form of cell death and is characterized by GSDMD (gasdermin D) or GSDME (gasdermin E)-mediated necrosis with excessive inflammatory factor ...

Upon CARD8 activation, caspase‐1 cleaves its pore‐forming substrate GSDMD which executes pyroptosis. Inflammasomes function as cytosolic sensors of microbial infection as well as perturbation of ...

2020年8月24日讯/生物谷BIOON/---2001年，Cookson等人首次使用pyroptosis来形容在巨噬细胞中发现的caspase-1依赖性细胞死亡方式。细胞 ...

Why does pyroptosis take place? Pyroptosis is a form of programmed cell death that occurs during intracellular pathogen infection, as part of the body's antimicrobial response. Cell-surface ...