Pyroptosis is an inflammatory form of cell death that plays important roles in host defense and inflammatory disorders. Despite intensive studies, the molecular events underlying the gasdermin D ...

This study aimed to investigate the role of NLRP3/caspase-1/gasdermin D (GSDMD)-mediated pyroptosis in hyperoxia-induced lung injury in neonatal mice and to evaluate the potential protective effects ...

Mechanistically, TRI-03 not only increases intracellular reactive oxygen species (ROS) levels by inhibiting TrxR1 activity but also decreases XIAP expression, leading to the activation of the ...

Purpose: Diabetic retinopathy is currently considered a chronic inflammatory disease involving NOD-like receptor family pyrin domain containing 3 inflammasome activation and retinal microglial ...

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China ...

本研究针对TP53突变型非小细胞肺癌(NSCLC)治疗困境，揭示了MDM2抑制剂RG7388通过激活ROS/p-p38/NOXA/caspase-3/GSDME信号轴诱导p53非依赖 ...

Necrosis can occur accidentally or can be induced by tightly regulated pathways. Over the past decades, different forms of regulated necrosis, including necroptosis, ferroptosis, pyroptosis, and ...

我们可以这样理解：细胞死亡程序的启动，相当于给细胞膜装上了由NINJ1构成的“预制薄弱点”。但这并不意味着细胞会立即“爆炸”。它进入了一种“待破裂”的脆弱状态。最终是否会发生灾难性的、完全的破裂，还取决于它所处的物理微环境。

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Cell death plays a pivotal role in various physiological and pathological processes. However, distinguishing between different cell death modes such as apoptosis and pyroptosis based on brightfield ...