Much of the difficulty of determining the contributions of individual residues to protein structure and function stems from the need to generate and evaluate a large number of mutants. The ...

The three-dimensional shape of a protein determines its function. This is because proteins form attachments and interact with many other molecules and structures inside organisms. The shape of a ...

The specific structure of a protein determines its unique biological function. (click on image to enlarge) (Image: National Human Genom Research Institute) Proteins are built from a set of 20 standard ...

The information DNA contains is the instructions that the cell uses to make proteins. Proteins play a big part in determining the characteristics of specialised cells and whole organisms.

In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA and then read ...

In the subsequent years, DeepMind created the AlphaFold Protein Structure Database, which now includes over 200 million structures. Access to these protein structures opened the door to a deeper ...

New research by scientists at the University of Toronto and the Structural Genomics Consortium has deepened our understanding ...

Although the rational protein design approach offers an increased possibility of beneficial alterations, it is not easy to accurately predict the sequence-structure-function relationship, particularly ...

The study shows how subtle changes in a protein’s sequence, within just a few non-active site amino acid residues, can lead ...

The rRNA molecules fold into complex secondary and tertiary structures, forming domains and motifs that are essential for ribosome function. The rRNA structures also provide binding sites for ...