A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

Traditional small-molecule inhibitor drugs typically jam a protein’s function like a wrench in the gears ... TPD relies on the tens of thousands of proteasomes already in each of our cells, explains ...

and impaired lysosomal function. These changes interact with other proteostasis systems, like the ubiquitin-proteasome pathway, amplifying vulnerabilities to neurodegenerative diseases.

and covalent modifications of proteasomal subunits—all well-established contributors to the progressive decline in proteasome function. Once initiated, this cycle would become self-perpetuating, with ...

Center for Cell Structure and Function, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China ...

Despite its critical importance, the molecular mechanisms that control protein homeostasis and proteasome function remain poorly understood. The Rousseau lab is interested in developing new ...

Medically reviewed by Lindsay Cook, PharmD Multiple myeloma (also referred to as myeloma) is a type of rare, incurable cancer of the blood—also known as hematologic cancer. It affects cells called ...

The Fn key is short for function – this particular key allows PC users to access the second assignment of a key. It is normally found at the bottom left corner. The Function keys (F1 ...