Molecular research has elucidated the mechanism controlling the developmental switch from fetal hemoglobin (HbF) to adult hemoglobin (HbA). BCL11A, the principal switch factor, which was ...

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The prolyl isomerase PIN1 has been identified as a ... Protein phosphorylation is a key cellular signalling mechanism that induces changes in protein conformation 1,2. For example, the ...

Jin X, Li P, Michalski D, Li S, Zhang Y, Jolkkonen J, Cui L, Didwischus N, Xuan W, Boltze J. Perioperative stroke: a perspective on challenges and opportunities for experimental treatment and ...

Prolyl oligopeptidase B from Galerina marginata (GmPOPB ... This work is the first step toward elucidating GmPOPB’s mechanism and should contribute to the engineering of more efficient macrocyclases.

In this context, this article briefly describes the pathological process of hepatic fibrosis and focuses on reviewing the progress of clinical studies on mechanism-based anti-fibrotic drug development ...