The prolyl isomerase PIN1 has been identified as a ... Protein phosphorylation is a key cellular signalling mechanism that induces changes in protein conformation 1,2. For example, the ...

1Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California.

† Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States ‡ Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, United States § Department of Chemistry and ...

The Pin1 prolyl isomerase acts in concert with proline-directed protein kinases to regulate function of protein substrates through isomerization of peptide bonds that link phosphoserine or ...

Here, we identified that Cyclophilin71 (CYP71), a peptidyl-prolyl isomerase (PPIase), positively regulates miRNA processing through ... suggest regulation of SE phase separation by peptidyl-prolyl cis ...

The peptidyl-prolyl isomerase Pin1 has wide-ranging influences on the occurrence and development of neurological diseases. It has also been suggested that Pin1 acts on epileptic inhibition, and the ...

Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Collaborative Innovation Center of Biotherapy, Chengdu, China ...

Ongar, UK – 27 November 2012. Selcia Limited, the international life sciences contract research organisation, has announced the launch of a new platform to enable drug discovery and development on the ...

Nuclear protein peptidyl-prolyl isomerase Pin1-mediated prolyl isomerization is an essential and novel regulatory mechanism for protein phosphorylation. Therefore, tight regulation of Pin1 ...