Department of Foundational Medical Studies, William Beaumont School of Medicine, Oakland University, Rochester, Michigan 48309, United States *Address: William Beaumont School of Medicine, Oakland ...

Cholesterol synthesis is both energy- and oxygen-intensive, yet relatively little is known of the regulatory effects of hypoxia on pathway enzymes. We previously showed that the rate-limiting and ...

The structural class of Vadadustat and Roxadustat is the same as for collagen prolyl-4-hydroxylase (CP4H) inhibitors which were patented more than 20 years ago (Weidmann et al., 1997). The simple ...

Prolyl hydroxylase (PHD) hydroxylates HIF-1α leading to its degradation ... They have deduced, and experimentally tested, the idea that during aerobic glycolysis the enzyme glyceraldehyde 3-phosphate ...