Here, the aim was to develop an ACPP sensitive to matrix metalloproteinase-2 and -9 (MMP-2/9) for nuclear imaging purposes. MMP-2/9 ACPPs and non-activatable cell-penetrating peptides (non-ACPP) were ...

SR9009 was found to exert REV-ERB–independent effects on proliferation, metabolism, and gene transcription in 2 different cell types depleted of REV-ERBs. Therefore, effects of these drugs cannot be ...

Background: Matrix metalloproteases (MMPs) are believed to be important in the pathogenesis of cigarette smoke-induced emphysema, but this hypothesis has only been proved in the mouse and its ...

Specific tissue expression of MMP-9 has been identified as a prognostic marker of healing of chronic ulcers. 10 A previous study has demonstrated high levels of both MMP-2 and MMP-9 in chronic VUs of ...

Cellular proliferation activity and response to the anticancer drug cisplatin were evaluated by cell counting using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. For the ...

This pathway possibly prepares the cells for a higher activity in a hypoxic or an angiogenic microenvironment. Other in vitro and in vivo studies may clarify the activation mechanism and the response ...

Keywords: miR-129-5p, gastric cancer, cancer metabolism, proliferation, SLC2A3. Citation: Chen D, Wang H, Chen J, Li Z, Li S, Hu Z, Huang S, Zhao Y and He X (2018) MicroRNA-129-5p Regulates Glycolysis ...

本研究针对妊娠高血压(PIH)中子宫动脉功能异常的核心问题，通过体内外实验揭示了PIGF通过激活KCNK2通道上调MMP-2/9表达的新 ...

Dry eye disease (DED) is a common disorder characterized by unstable tear film homeostasis. Its symptoms range from foreign body sensations to pain and fluctuations in visual function. Current ...

The cytotoxicity of 1 and 4 were evaluated against HL-60, PANK-1, HepG2, HT-29, and T98G cell lines, as well as their effects on cell proliferation in the skin keratinocyte cell line HaCaT. These ...

Background: The proteolytic enzyme matrix metalloproteinase (MMP)-9 can degrade structural compounds such as the extracellular matrix and the basement membrane in the airways and lungs. MMP-9 has ...

Interleukin 15 (IL-15) is an essential cytokine for the survival and proliferation of natural killer (NK) cells. IL-15 activates signaling by the β and common γ (γc) chain heterodimer of the IL-2 r ..