Department of Pharmaceutical Sciences, College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065 Article Views are the COUNTER-compliant sum of full text ...

An investigational viral immunotherapy (CAN-2409; aglatimagene besadenovec) combined with a prodrug improved disease-free survival (DFS) when added to standard curative-intent radiotherapy for newly ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Analyses of potential prodrug failure ...

Examples of the most frequently studied applications are listed in sub-sections below. It is to be noted, however, that possible prodrug applications are not restricted to those listed.

Examples include matrix metalloproteinase (MMP ... AMX-818, also known as SAR446309, designed with the PRO-XTEN masking platform, is a novel prodrug HER2-XPAT TCE exhibiting potent T cell activation ...

aCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA bHenan-Macquarie Uni Joint Centre for Biomedical Innovation, ...

Elysium Therapeutics today announced positive results from a Phase 1, human-proof-of-concept study (O2P-001) investigating the company's proprietary Oral Overdose Protected (O2P™) hydrocodone prodrug ...

FIGURE 3. Example of gut microbiota biotransformation of trans-resveratrol. Most Chinese herbal medicines are poor aqueous solubility, low bioavailability and stability, and non-target specificity, ...

For example, liver-targeted prodrug delivery was achieved by harnessing the distinct substrate specificity of the liver-specific isoform of P450, CYP3A4 (Erion et al., 2005; Erion et al., 2004).