本研究针对HIV-1潜伏期逆转的临床挑战，揭示了病毒反义转录本（AST）通过招募PRC2复合体（Polycomb repressor complex 2）和宿主因子（如SMARCD2、PTBP1）形成多分子凝聚体，在CD4+ T细胞中抑制5′ LTR（长末端重复序列）的转录激活。通过结构域突变和蛋白质组学分析，明确了AST的U3结构域（含Y-rich基序）和B ...

Specifically, she identified one of the sequestered proteins was RNF2, the catalytic subunit of the polycomb repressor complex 1 (PRC1), which is an important transcriptional repressor. Additionally, ...

By genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation ...