I was working in Kari Alitalo's laboratory as a Ph.D. student. We were at the "cutting edge" of technology because we used a software program called Gene Construction Kit (GCK) to keep track of our ...

Plasmid copy number within a strain is largely set by vector-intrinsic factors. Gene therapy or DNA vaccine plasmids typically contain either the pUC or pMM1 temperature-sensitive origin of ...

Plasmid DNA lies at the heart of viral and mRNA vector production because it provides the coding sequences for gene-based advanced therapy medicinal products (ATMPs). Its manufacture is therefore ...

The addition of in-stock packaging plasmids for RG, HQ, and GMP grade plasmids, combined with Charles River’s established plasmid and viral vector CDMO capabilities, will help to both accelerate ...