Plasma cell leukemia (PCL) is a rare disease that may present de novoor secondary to plasma cell myeloma. Advanced disease and extramedullary involvement are common clinical features at presentation.

During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

Plasmacytoid dendritic cells (pDCs) are a subset of dendritic cells. They resemble plasma cells when viewed under a microscope and are distinct from conventional dendritic cells in terms of their ...