Here the authors show the presence of PD-L1 expressing regulatory plasma cells that can inhibit T cells in a murine model and in patients with sepsis. Plasma cell differentiation is governed by a ...

Plasma Cell Neoplasms: These can appear similar to PC-CD, especially when monotypic plasma cell populations are present. ・ IgG4-related Disease (IgG4-RD): Frequently overlaps with PC-CD and iMCD ...

BPDCN is an aggressive type of blood cancer that originates from plasmacytoid dendritic cells (pDCs), a component of the immune system that produces type 1 interferon cytokines. These cytokines ...

Plasma cell leukemia (PCL) is a rare disease that may present de novoor secondary to plasma cell myeloma. Advanced disease and extramedullary involvement are common clinical features at presentation.

Neoplastic cell morphology in peripheral blood (A) and bone marrow aspirate films (B) showing small- to medium-sized lymphoplasmacytic lymphocytes (May Grunwald Giemsa stain, 1000×). Bone marrow ...

However, data on the dietary habits of individuals with plasma cell disorders (PCDs) remains limited. Methods: We surveyed 443 individuals with MGUS, SMM, or MM on HealthTree Cure Hub using the Block ...

However, the role of tumour-infiltrating B cells (TIBs) remains controversial. Here, we investigate the impact of TIBs and their interaction with T cells on HCC patient prognosis. Design Tissue ...

A neoplasm is an abnormal growth of cells in the body. It happens when the body’s normal process of making and replacing cells doesn’t work as it should. When a neoplasm forms into an abnormal growth, ...

Activation-induced cytidine deaminase (AID) serves as a critical molecular orchestrator in the germinal center (GC) reaction within secondary lymphoid organs (SLOs), driving the production of ...