The sensitivity and comprehensive phosphorylation site mapping of this approach was demonstrated by using two standard phosphoprotein samples of α-casein and β-casein, and this approach was further ...

Since the phosphorylation of DAG into PA at PM (trans) or the ER (cis) has distinct functional consequences, determining its specific location activity is important. To address this, loss-of-function ...

The possibility that tyrosine phosphorylation site usage within an ErbB receptor may be influenced by its heterodimerizing partner (Olayioye et al., 1998) further substantiates a role for ...

Kinase inhibitors are key in cancer therapy, but resistance limits their efficacy. Here, the authors develop SPIED-DIA, a phosphoproteomics method enhancing detection of key phosphorylation sites.

Overall, our biochemical experiments indicate that the existence of a single phosphorylation site at the S551 position in SIK3 is crucial for recognition by PKA and interaction with 14-3-3. We presume ...

Erythritol may impair cellular functions essential to maintaining brain blood vessel health, according to researchers at the ...

MIT researchers found that high-fat diets cause metabolic enzyme dysfunction and insulin resistance by increasing reactive oxygen species in cells. However, antioxidants reversed much of the damage in ...

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Scientists at the Broad Institute of MIT and Harvard have identified 4,208 previously unannotated open reading frames (ORFs) across 679 human-associated viral genomes using a high-throughput method ...

Professor Sun Jinpeng's team and Professor Yu Xiao's team at Shandong University, collaborating with Professor Jiang Changtao from Peking University, Professor Pang Yanli, and Professor Ji Linong, ...

The study sheds light on a crucial protein, PfPPM2, which controls asexual division and switching between the sexual forms in ...

CARDIFF, UNITED KINGDOM / ACCESS Newswire / June 18, 2025 / When it comes to type 1 diabetes, treating this chronic condition ...