Despite being one of the most widely used pain relievers on the planet, scientists have had trouble figuring out how ...

Instead, U-50488 likely mediated its peripheral analgesic effect through nonselective inhibition of voltage-gated sodium channels, including peripheral sensory neuron isoforms Na V 1.8 and Na V 1.7.

To perform these processes and others, like crawling or exploring, octopuses rely on their complex nervous system, one that ...

A team from UCL Centre for Nerve Engineering have developed an off-the-shelf cell therapy for the repair of peripheral nerve injury called Engineered Neural Tissue (EngNT). EngNT will provide a living ...

AIMS To study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the ...

Human dorsal root ganglia in a case of diabetic peripheral neuropathy show formation of Nageotte nodules (circled in pink), which appear to be a strong indicator of nerve cell death.(University of ...

Abstract: We have investigated the alterations that the long-term implant of sieve electrodes to the peripheral nerves could evoke in the central nervous system by studying the neural activity at ...

A full assessment of these issues is critical to the successful implementation of bilayer NGCs in peripheral nerve repair. In the present work, we used dorsal root ganglia (DRG) as a model system to ...

For their study, the researchers used both young and aged mice to examine how peripheral nerve injury and age influence the development of cellular senescence in sensory neurons. The team studied the ...

About Tanruprubart (formerly ANX005) Annexon’s lead investigational therapy, tanruprubart, is a first-of-its kind selective, targeted and rapid-acting agent designed to reduce inflammation and nerve ...

Annexon's lead investigational therapy, tanruprubart, is a first-of-its kind selective, targeted and rapid-acting agent designed to reduce inflammation and nerve damage by stopping C1q activity in the ...