Angiopep-2脑肽修饰的PEG-PEI-PCL阳离子聚合物纳米粒包载TMZ 和 siRNA Angiopep-2 是一种肽类分子，能够特异性识别和结合肿瘤血管内皮细胞表面上高度表达的低密度脂蛋白受体相关蛋白（LRP-1）；Angiopep-2 作为靶向分子，能够增强纳米载体对肿瘤细胞的靶向性，提高药物 ...

Other forms of transfection agents are also based ... [CDs]) or from synthetic polymers such as polyethyleneimine (PEI). Targeted siRNA Delivery The ability to target specific cell types provides ...

Cationic charges in siRNA carriers can be provided by various materials, most typically polymers, lipids and inorganic nanomaterials. Inflammatory toxicity: lipoplexes are captured by Kupffer ...

Cancer cells often display centrosome amplification, requiring the kinesin KIFC1/HSET for centrosome clustering to prevent multipolar spindles and cell death. In parallel siRNA screens of ...

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China Institute of Functional Nano and Soft Materials, Jiangsu Key Laboratory for ...

Mechanobiology Institute Singapore, National University of Singapore, Singapore 117411, Singapore ...

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The complement system and neutrophils ...

LX-2 cells were transfected with siRNA, which was designed and synthesized by RiboBio in Guangzhou, China. Transfection was carried out using Lipofectamine 3000 (Invitrogen; Carlsbad; USA) at a ...

Prince Edward Island will host five days and nights of performance and song from March 4 to 8, during the 2025 Music P.E.I. Week. With a full slate of shows at venues across the province, this year’s ...