Today, the overall survival for children with malignancies approaches 80% and is truly one of the success stories in modern day medicine (1). The progress in the treatment of pediatric malignancy ...

Introduction: Hematologic malignancies, including leukemias, lymphomas, and myeloma, can involve the central nervous system (CNS) at the time of diagnosis or later in relapse. CNS involvement can lead ...

[1–3] We will discuss the usage of mAbs targeting pediatric solid tumors ... or refractory medulloblastoma or CNS primitive neuroectodermal tumors National Cancer Institute NCT01222715 ...

This is the largest number of positive recommendations in a single year for blood cancer treatments. NICE has made almost 100 positive blood cancer treatment recommendations in the last decade. Blood ...

In contrast, mostly H4 is detectable in the CSF of pediatric patients with blood malignancies. Discussion: In conclusion, free histones and histone complexes are detectable with a strong signal in the ...